Treatment outcomes and prognostic factors, including human papillomavirus, for sinonasal undifferentiated carcinoma: a retrospective review.

Abstract

BACKGROUND:

Sinonasal undifferentiated carcinoma (SNUC) is a high-grade, aggressive neoplasm. Low incidence and poor outcomes make identification of prognostic factors and treatment standardization difficult. Similarly, little is known regarding the association of human papillomavirus (HPV) with SNUC.

METHODS:

A retrospective review was conducted. Extracted information included treatment received, tumor recurrence, patient survival, p16 expression, and HPV status. The Kaplan-Meier method was used to estimate overall survival (OS) and disease-free survival (DFS). Survival trends were compared using the log-rank test.

RESULTS:

Nineteen patients received multimodality treatment for SNUC. Five-year OS and DFS rates were 45.2% and 50.7%, respectively, with no significant difference between treatment types. Tumors from 11 patients were p16-positive and 9 of these were also HPV-positive. Kaplan-Meier analysis demonstrated improved survival.

CONCLUSION:

Our series demonstrates a higher prevalence of HPV in SNUC than previously reported. HPV-positive SNUCs may benefit from improved survival and should be investigated further in future studies.

• Authors: Stacey T Gray, Marc W Herr, Rosh K V Sethi, Gillian Diercks, Linda Lee, William Curry, Annie Chan, John Clark, Eric H Holbrook, James Rocco, Peter M Sadow, Derrick T Lin
• Journal: Head & neck (Head Neck) Vol. 37 Issue 3 Pg. 366-74 (Mar 2015) ISSN: 1097-0347 [Electronic] United States
• PMID: 24421248 (Publication Type: Journal Article)
• Copyright: © 2014 Wiley Periodicals, Inc.

Topics

• Adult
• Aged
• Carcinoma (mortality, pathology, therapy, virology)
• Cohort Studies
• Combined Modality Therapy
• Disease-Free Survival
• Female
• Humans
• Kaplan-Meier Estimate
• Male
• Maxillary Sinus Neoplasms (mortality, pathology, therapy, virology)
• Middle Aged
• Neoplasm Invasiveness (pathology)
• Neoplasm Recurrence, Local (mortality, pathology)
• Neoplasm Staging
• Papillomaviridae (isolation & purification)
• Papillomavirus Infections (diagnosis, therapy)
• Paranasal Sinus Neoplasms (mortality, pathology, therapy, virology)
• Prognosis
• Retrospective Studies
• Survival Analysis
• Time Factors
• Treatment Outcome