Abstract |
D-Galactofuranose (D-Galf) is present in glycoconjugates of several pathogenic microorganisms but is absent in mammals, so it is a good target for the development of chemotherapeutic agents for the treatment of microbial infections. This fact has increased interest in the synthesis of D-Galf-containing molecules for corresponding glycobiological studies. The synthesis of oligosaccharides, glycoconjugates, and mimetics of D-Galf requires specific methods for the preparation of galactose derivatives in the furanosic configuration, the synthesis of appropriate acceptors, and efficient glycosylation methods for the construction of α- and β-D-Galf linkages. This review summarizes the different strategies developed for the preparation of partially protected derivatives of D-Galf, suitable as acceptors for the construction of (1→2), (1→3), (1→5), and (1→6) link- ages, and describes recent applications.
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Authors | Carla Marino, Luciana Baldoni |
Journal | Chembiochem : a European journal of chemical biology
(Chembiochem)
Vol. 15
Issue 2
Pg. 188-204
(Jan 24 2014)
ISSN: 1439-7633 [Electronic] Germany |
PMID | 24420700
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Copyright | Copyright © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Chemical References |
- Glycoconjugates
- Polysaccharides
- Galactose
|
Topics |
- Chemistry Techniques, Synthetic
(methods)
- Drug Design
- Galactose
(chemistry)
- Glycoconjugates
(chemical synthesis, chemistry)
- Glycosylation
- Polysaccharides
(chemical synthesis, chemistry)
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