HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Expression and function of a novel isoform of Sox5 in malignant B cells.

Abstract
Using a mouse model with the tumor suppressor TRAF3 deleted from B cells, we identified Sox5 as a gene strikingly up-regulated in B lymphomas. Sox5 proteins were not detected in normal or premalignant TRAF3(-/-) B cells even after treatment with B cell stimuli. The Sox5 expressed in TRAF3(-/-) B lymphomas represents a novel isoform of Sox5, and was localized in the nucleus of malignant B cells. Overexpression of Sox5 inhibited cell cycle progression, and up-regulated the protein levels of p27 and β-catenin in human multiple myeloma cells. Together, our findings indicate that Sox5 regulates the proliferation of malignant B cells.
AuthorsShanique K E Edwards, Anand Desai, Yan Liu, Carissa R Moore, Ping Xie
JournalLeukemia research (Leuk Res) Vol. 38 Issue 3 Pg. 393-401 (Mar 2014) ISSN: 1873-5835 [Electronic] England
PMID24418753 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Antibodies
  • CTNNB1 protein, human
  • Lipopolysaccharides
  • Proliferating Cell Nuclear Antigen
  • Protein Isoforms
  • SOXD Transcription Factors
  • Sox5 protein, mouse
  • TNF Receptor-Associated Factor 3
  • beta Catenin
  • p27 antigen
Topics
  • Animals
  • Antibodies (pharmacology)
  • B-Lymphocytes (drug effects, metabolism, pathology)
  • Cell Cycle (genetics)
  • Cell Nucleus (genetics, metabolism, ultrastructure)
  • Cell Proliferation
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lipopolysaccharides (pharmacology)
  • Lymphocyte Activation (drug effects)
  • Mice
  • Proliferating Cell Nuclear Antigen (genetics, metabolism)
  • Protein Isoforms (genetics, metabolism)
  • SOXD Transcription Factors (genetics, metabolism)
  • Signal Transduction
  • TNF Receptor-Associated Factor 3 (deficiency, genetics)
  • beta Catenin (genetics, metabolism)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: