Toxicity of nano molybdenum trioxide toward invasive breast cancer cells.

Abstract

Current chemotherapy is limited by the nature of invasive cancer cells, which are similar to cancer stem cells. Nanomaterials provide a potential alternate mode of cancer therapy. This study investigated the cytotoxicity of molybdenum trioxide (MoO3) nanoplates toward invasive breast cancer iMCF-7 cells by analyzing morphological changes and performing Western blot and flow cytometry analyses. The findings suggested that MoO3 exposure induces apoptosis and generates reactive oxygen species (ROS) in iMCF-7 cells. This study revealed the potential utility of MoO3 for treating metastatic cancer cells, which might enable advancements in cancer therapy.

• Authors: Thao Anh Tran, Karthikeyan Krishnamoorthy, Yeon Woo Song, Somi Kim Cho, Sang Jae Kim
• Journal: ACS applied materials & interfaces (ACS Appl Mater Interfaces) Vol. 6 Issue 4 Pg. 2980-6 (Feb 26 2014) ISSN: 1944-8252 [Electronic] United States
• PMID: 24417578 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Oxides
• molybdenum trioxide
• Molybdenum

Topics

• Blotting, Western
• Breast Neoplasms (pathology)
• Female
• Humans
• MCF-7 Cells
• Metal Nanoparticles (chemistry, toxicity)
• Molybdenum (chemistry, toxicity)
• Neoplasm Invasiveness
• Oxides (chemistry, toxicity)
• X-Ray Diffraction