Abstract | CONTEXT:
Cadmium oxide nanoparticles (CdO NPs) are employed in optoelectronic devices and as a starting material for generating quantum dots as well as for medical imaging and targeting of pharmaceutical agents to disease sites. However, there are lack of data concerning short- and long-term effects of CdO NPs on the lungs. OBJECTIVE: To determine the effects of inhaled CdO NPs at an occupationally relevant concentration on pulmonary injury and repair, and on systemic immunity in adult male mice. METHODS: Mice were exposed to 240 μg CdO NPs/m(3) for seven days (3 h/d) and lavage levels of pulmonary injury/inflammatory markers, bacterial uptake by circulating phagocytes, and lung histology examined either one or seven days following the final exposure. RESULTS: CONCLUSIONS: This study demonstrates that short-term inhalation exposure to CdO NPs can stimulate pathways in the lungs associated with inflammation, cell injury, and tissue remodeling as well as alter immune function. Findings here demonstrate that even short-term inhalation exposure to CdO NPs in the workplace could lead to deleterious pulmonary effects in exposed workers.
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Authors | Jason L Blum, Lauren K Rosenblum, Gabriele Grunig, Mary Beth Beasley, Judy Q Xiong, Judith T Zelikoff |
Journal | Inhalation toxicology
(Inhal Toxicol)
Vol. 26
Issue 1
Pg. 48-58
(Jan 2014)
ISSN: 1091-7691 [Electronic] England |
PMID | 24417406
(Publication Type: Journal Article)
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Chemical References |
- Cadmium Compounds
- Cytokines
- Oxides
- cadmium oxide
- L-Lactate Dehydrogenase
- Matrix Metalloproteinase 2
- Mmp2 protein, mouse
- Matrix Metalloproteinase 9
- Mmp9 protein, mouse
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Topics |
- Administration, Inhalation
- Animals
- Bronchoalveolar Lavage Fluid
(chemistry, cytology)
- Cadmium Compounds
(toxicity)
- Cytokines
(immunology)
- Disease Models, Animal
- Escherichia coli
- L-Lactate Dehydrogenase
(immunology)
- Leukocyte Count
- Lung
(drug effects, immunology, pathology)
- Lung Injury
(chemically induced, immunology, pathology)
- Male
- Matrix Metalloproteinase 2
(immunology)
- Matrix Metalloproteinase 9
(immunology)
- Metal Nanoparticles
(toxicity)
- Mice
- Oxides
(toxicity)
- Phagocytosis
(drug effects)
- Pneumonia
(chemically induced, immunology, pathology)
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