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Luteolin reduces Alzheimer's disease pathologies induced by traumatic brain injury.

Abstract
Traumatic brain injury (TBI) occurs in response to an acute insult to the head and is recognized as a major risk factor for Alzheimer's disease (AD). Indeed, recent studies have suggested a pathological overlap between TBI and AD, with both conditions exhibiting amyloid-beta (Aβ) deposits, tauopathy, and neuroinflammation. Additional studies involving animal models of AD indicate that some AD-related genotypic determinants may be critical factors enhancing temporal and phenotypic symptoms of TBI. Thus in the present study, we examined sub-acute effects of moderate TBI delivered by a gas-driven shock tube device in Aβ depositing Tg2576 mice. Three days later, significant increases in b-amyloid deposition, glycogen synthase-3 (GSK-3) activation, phospho-tau, and pro-inflammatory cytokines were observed. Importantly, peripheral treatment with the naturally occurring flavonoid, luteolin, significantly abolished these accelerated pathologies. This study lays the groundwork for a safe and natural compound that could prevent or treat TBI with minimal or no deleterious side effects in combat personnel and others at risk or who have experienced TBI.
AuthorsDarrell Sawmiller, Song Li, Md Shahaduzzaman, Adam J Smith, Demian Obregon, Brian Giunta, Cesar V Borlongan, Paul R Sanberg, Jun Tan
JournalInternational journal of molecular sciences (Int J Mol Sci) Vol. 15 Issue 1 Pg. 895-904 (Jan 09 2014) ISSN: 1422-0067 [Electronic] Switzerland
PMID24413756 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References
  • Amyloid beta-Peptides
  • Cytokines
  • tau Proteins
  • Glycogen Synthase Kinase 3
  • Luteolin
Topics
  • Alzheimer Disease (drug therapy, etiology)
  • Amyloid beta-Peptides (metabolism)
  • Animals
  • Brain (drug effects, metabolism)
  • Brain Injuries (complications, drug therapy)
  • Cytokines (genetics, metabolism)
  • Glycogen Synthase Kinase 3 (metabolism)
  • Luteolin (pharmacokinetics, pharmacology, therapeutic use)
  • Mice
  • Tissue Distribution
  • tau Proteins (metabolism)

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