Effect of the new specific bradycardia agent AQ-A39 (falipamil) on coronary collateral blood flow in dogs.

Abstract

The effect of two doses (0.5 and 1.0 mg/kg i.v.) of a new specific bradycardic agent, AQ-A39 (5,6-dimethoxy-2-[3- [( alpha- (3,4,-dimethoxy)phenylethyl]methyl-amino)propyl]phthalimidine hydrochloride), on three indices of collateral function--retrograde pressure, retrograde flow, and tissue blood flow (radioactive microspheres)--was studied in anesthetized dogs following acute occlusion of the left anterior descending coronary artery. AQ-A39 produced a significant (p less than 0.05) dose-related decrease in heart rate without any other hemodynamic changes. Retrograde flow and subendocardial blood flow were significantly increased by the lower dose of AQ-A39, whereas retrograde pressure, retrograde flow, and midmyocardial and subendocardial flow were increased by the higher dose. Atrial pacing to the control heart rate eliminated the beneficial effects of AQ-A39 on collateral function. These results suggest that an increase in collateral perfusion may be one mechanism by which AQ-A39 alleviates myocardial ischemia.

• Authors: G J Gross, J W Daemmgen
• Journal: Journal of cardiovascular pharmacology (J Cardiovasc Pharmacol) Vol. 10 Issue 1 Pg. 123-7 (Jul 1987) ISSN: 0160-2446 [Print] United States
• PMID: 2441148 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Cardiovascular Agents
• Isoindoles
• Phthalimides
• falipamil

Topics

• Animals
• Bradycardia (chemically induced)
• Cardiovascular Agents (pharmacology)
• Collateral Circulation (drug effects)
• Coronary Circulation (drug effects)
• Dogs
• Female
• Hemodynamics (drug effects)
• Isoindoles
• Male
• Phthalimides (pharmacology)
• Regional Blood Flow (drug effects)