Fibroblast growth factor receptor 4 as a potential prognostic and therapeutic marker in colorectal cancer.

Abstract

The purpose of the study was to explore the significance of FGFR4 protein expression in colorectal cancer. Immunohistochemistry showed 46.8% (148/316) tumors positive for FGFR4 and 7.3% (23/316) for adjacent normal specimens. FGFR4 positivity was correlated with shortened disease free survival (DFS) and overall survival (OS). Multivariate analysis revealed that FGFR4 was an independent prognostic factor. FGFR4 silencing markedly reduced the migration and invasion capacity of colorectal cancer cell lines. These results suggest FGFR4 is a potential prognostic and therapeutic marker for colorectal cancer.

• Authors: Chen-Sheng Li, Shu-Xiang Zhang, Hong-Jun Liu, Yu-Long Shi, Le-Ping Li, Xiao-Bo Guo, Zhen-Hai Zhang
• Journal: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals (Biomarkers) Vol. 19 Issue 1 Pg. 81-5 (Feb 2014) ISSN: 1366-5804 [Electronic] England
• PMID: 24410190 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• FGFR4 protein, human
• Receptor, Fibroblast Growth Factor, Type 4

Topics

• Aged
• Biomarkers, Tumor (genetics, metabolism)
• Cell Line, Tumor
• Cell Movement
• Colorectal Neoplasms (metabolism, mortality)
• Female
• Gene Expression
• Gene Knockdown Techniques
• Humans
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Prognosis
• Proportional Hazards Models
• Receptor, Fibroblast Growth Factor, Type 4 (genetics, metabolism)