Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India.

Abstract

AIM:

The present study was designed to investigate whether the three-apolipoprotein (AI, B, E) gene polymorphisms were related to alter their plasma protein levels and hence associated to coronary artery disease (CAD).

METHODS:

We determined distribution of MspI apo AI, EcoRI apo B, HhaI apo E gene polymorphisms, plasma apolipoproteins and lipids levels among 150 patients having CAD admitted to the Department of Cardiology, N.R.S. Medical College & Hospital, Kolkata, India during June 2010-June 2012 and 150 age sex matched healthy controls.

RESULTS:

We found that ApoAI concentration of studied population was significantly different in each genotypes of -75 G/A apo AI (p < 0.0001) gene polymorphism. A significant association was found in multivariate analysis for the genotypes with apo E4 allele [odds ratio (OR): 3.639; 95% confidence interval (CI): 1.019-12.995, p = 0.040] with four conventional risk factors (i.e. smoking, low-density lipoprotein, ApoAI and ApoB) with CAD. In contrast E2 allele has reverse effect, but the genotypes with apo E2 allele was no longer significant in the multivariate model (OR: 1.788; 95% CI: 0.400-8.001, p = 0.447) where as being significant in univariate analysis (OR: 0.219; 95% CI: 0.087-0.552, p = 0.001).

CONCLUSIONS:

Our findings suggest that the polymorphisms apo AI MspI and apo B EcoRI do not seem to affect CAD. But the genotype with E4 allele of apo E gene independent of other risk factors is associated with this disease.

• Authors: Santanu Biswas, Pradip K Ghoshal, Bhubaneswar Halder, Kajal Ganguly, Arup DasBiswas, Nripendranath Mandal
• Journal: Indian heart journal (Indian Heart J) Vol. 65 Issue 6 Pg. 658-65 (Dec 2013) ISSN: 2213-3763 [Electronic] India
• PMID: 24407534 (Publication Type: Comparative Study, Journal Article)
• Copyright: Copyright © 2013 Cardiological Society of India. Published by Elsevier B.V. All rights reserved.

Chemical References

• Apolipoprotein A-I
• Apolipoproteins B
• Apolipoproteins E

Topics

• Aged
• Alleles
• Apolipoprotein A-I (blood, genetics)
• Apolipoproteins B (blood, genetics)
• Apolipoproteins E (blood, genetics)
• Case-Control Studies
• Confidence Intervals
• Coronary Artery Disease (diagnostic imaging, epidemiology, genetics)
• Female
• Genetic Predisposition to Disease (epidemiology)
• Genotype
• Humans
• Incidence
• India (epidemiology)
• Male
• Middle Aged
• Multivariate Analysis
• Odds Ratio
• Polymorphism, Genetic
• Radiography
• Risk Assessment
• Survival Analysis
• Tertiary Care Centers