Abstract | BACKGROUND: METHODS: Exposure to early childhood PAHs was measured by two week residential indoor monitoring at age 5-6 years in the Columbia Center for Children's Environmental Health birth cohort (n=311). Semivolatile [e.g., methylphenanthrenes] and nonvolatile [e.g., benzo(a)pyrene] PAHs were monitored. Obesity at age 5 was defined as a body mass index (BMI) greater than or equal to the 95th percentile of the year 2000 age- and sex-specific growth charts (Center for Disease Control). Current asthma and recent wheeze at ages 5 and 7 were determined by validated questionnaires. Data were analyzed using a modified Poisson regression in generalized estimating equations (GEE) to estimate relative risks (RR), after adjusting for potential covariates. RESULTS: Neither PAH concentrations or obesity had a main effect on asthma or recent wheeze. In models stratified by presence/absence of obesity, a significant positive association was observed between an interquartile range (IQR) increase in natural log-transformed 1-methylphenanthrene (RR [95% CI]: 2.62 [1.17-5.88] with IQRln=0.76), and 9-methylphenanthrene (2.92 [1.09-7.82] with IQRln=0.73) concentrations and asthma in obese children (n=63). No association in non-obese (n=248) children was observed at age 5 (Pinteraction<0.03). Similar associations were observed for 3-methylphenanthrene, 9-methylphenanthrene, and 3,6-dimethylphenanthrene at age 7. CONCLUSIONS: Obese young children may be more likely to develop asthma in association with greater exposure to PAHs, and methylphenanthrenes in particular, than non-obese children.
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Authors | Kyung Hwa Jung, Matthew Perzanowski, Andrew Rundle, Kathleen Moors, Beizhan Yan, Steven N Chillrud, Robin Whyatt, David Camann, Frederica P Perera, Rachel L Miller |
Journal | Environmental research
(Environ Res)
Vol. 128
Pg. 35-41
(Jan 2014)
ISSN: 1096-0953 [Electronic] Netherlands |
PMID | 24407477
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Polycyclic Aromatic Hydrocarbons
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Topics |
- Asthma
(epidemiology, etiology)
- Child
- Child, Preschool
- Cohort Studies
- Female
- Humans
- Infant
- Male
- New York City
(epidemiology)
- Obesity
(complications)
- Polycyclic Aromatic Hydrocarbons
(adverse effects)
- Pregnancy
- Urban Population
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