[Alterations of SP-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluid in children with Mycoplasma pneumoniae pneumonia].

Abstract

OBJECTIVE:

To study the alterations and relationship of surfactant protein (SP)-A, SP-D and KL-6 in serum and bronchoalveolar lavage fluids (BALF) in children with Mycoplasma pneumoniae pneumonia (MPP).

METHOD:

Self-control method was used for the study on SP-A, SP-D and KL-6 in serum, infected and non-infected BALFs in 32 MMP children with only one side of MPP.

RESULT:

The contents of SP-A, SP-D and KL-6 in infected BALF were [mg/L;M (IQR) ]: 243 (90-468) , 187 (43-333) , 148 (47-426) ;104 (37-257) , 56 (25-131) , 35 (12-147) in non-infected BALF; 35 (25-69) , 33 (9-149) and 24 (15-62) in serum. The correlation coefficient of KL-6 between serum and infected BALF were -0.534 and -0.378 (P < 0.05).

CONCLUSION:

There were significant correlation between the alterations of SP-A, SP-D and KL-6 in serum and lung infection in children with CAP. KL-6 in serum may be more sensitive than SP-A and SP-D.

• Authors: Lin-hua Shu, Yun-xiao Shang, Xu-xu Cai, Zhi-hong Zong, Xiao-na Meng, Han Zhang, Zhi-jia Wang, Bing Dai
• Journal: Zhonghua er ke za zhi = Chinese journal of pediatrics (Zhonghua Er Ke Za Zhi) Vol. 51 Issue 10 Pg. 779-82 (Oct 2013) ISSN: 0578-1310 [Print] China
• PMID: 24406233 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers
• MUC1 protein, human
• Mucin-1
• Pulmonary Surfactant-Associated Protein A
• Pulmonary Surfactant-Associated Protein D

Topics

• Adolescent
• Biomarkers (blood, metabolism)
• Bronchoalveolar Lavage Fluid (chemistry)
• Child
• Child, Preschool
• Female
• Humans
• Infant
• Lung (metabolism, pathology)
• Male
• Mucin-1 (blood, metabolism)
• Pneumonia, Mycoplasma (blood, metabolism)
• Pulmonary Surfactant-Associated Protein A (blood, metabolism)
• Pulmonary Surfactant-Associated Protein D (blood, metabolism)
• Severity of Illness Index