Abstract |
Approximately 67% of peripheral blood lymphocytes in a case of nonmycosis fungoides-type cutaneous T-cell lymphoma, exhibited Sézary-like changes. Immunotyping showed a helper phenotype with an abnormally faint expression of the T3 membrane antigen, while quantitative electron microscopic study was suggestive of neoplasia. However, T-cell receptor gene study did not show any DNA rearrangement in Ficoll-separated blood lymphocytes, whereas clonal T-cell proliferation was simultaneously evidenced in cutaneous (non-Sézary-like) tumor cells. It is concluded that reactive nonneoplastic Sézary-like cells may be present not only in various benign conditions, as previously known, but also in T-cell lymphomas. This study provides further evidence for the nonspecificity of Sézary-like changes, and stresses the utility of T-cell receptor gene rearrangement study for diagnostic and prognostic procedures during the course of T-cell lymphoproliferative disorders.
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Authors | A Bendelac, N T O'Connor, M T Daniel, C Boitard, C Michel, L Laroche, P Lesavre, J F Bach |
Journal | Cancer
(Cancer)
Vol. 60
Issue 5
Pg. 980-6
(Sep 01 1987)
ISSN: 0008-543X [Print] United States |
PMID | 2440555
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- DNA, Neoplasm
(analysis)
- Diagnosis, Differential
- Fluorescent Antibody Technique
- Humans
- Lymphoma
(blood)
- Microscopy, Electron
- Middle Aged
- Neoplastic Cells, Circulating
- Sezary Syndrome
(blood)
- Skin Neoplasms
(blood)
- Staining and Labeling
- T-Lymphocytes
(pathology, ultrastructure)
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