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Nonneoplastic circulating Sézary-like cells in cutaneous T-cell lymphoma. Ultrastructural, immunologic, and T-cell receptor gene-rearrangement studies.

Abstract
Approximately 67% of peripheral blood lymphocytes in a case of nonmycosis fungoides-type cutaneous T-cell lymphoma, exhibited Sézary-like changes. Immunotyping showed a helper phenotype with an abnormally faint expression of the T3 membrane antigen, while quantitative electron microscopic study was suggestive of neoplasia. However, T-cell receptor gene study did not show any DNA rearrangement in Ficoll-separated blood lymphocytes, whereas clonal T-cell proliferation was simultaneously evidenced in cutaneous (non-Sézary-like) tumor cells. It is concluded that reactive nonneoplastic Sézary-like cells may be present not only in various benign conditions, as previously known, but also in T-cell lymphomas. This study provides further evidence for the nonspecificity of Sézary-like changes, and stresses the utility of T-cell receptor gene rearrangement study for diagnostic and prognostic procedures during the course of T-cell lymphoproliferative disorders.
AuthorsA Bendelac, N T O'Connor, M T Daniel, C Boitard, C Michel, L Laroche, P Lesavre, J F Bach
JournalCancer (Cancer) Vol. 60 Issue 5 Pg. 980-6 (Sep 01 1987) ISSN: 0008-543X [Print] United States
PMID2440555 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • DNA, Neoplasm
Topics
  • DNA, Neoplasm (analysis)
  • Diagnosis, Differential
  • Fluorescent Antibody Technique
  • Humans
  • Lymphoma (blood)
  • Microscopy, Electron
  • Middle Aged
  • Neoplastic Cells, Circulating
  • Sezary Syndrome (blood)
  • Skin Neoplasms (blood)
  • Staining and Labeling
  • T-Lymphocytes (pathology, ultrastructure)

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