Expression of cytokeratin 20 indicates invasive histological phenotype in poorly differentiated colorectal adenocarcinoma.

Abstract

BACKGROUND/AIM:

Cytokeratin (CK) 20 expression is an independent prognostic factor of poorly differentiated adenocarcinoma (PDA) of the colon and rectum. We aimed to investigate the mechanism of its involvement through a clinicopathological study.

PATIENTS AND METHODS:

We analyzed 156 surgically resected PDAs, which were sub-classified as solid type (Por1) showing expansive growth, or non-solid type (Por2) showing infiltrative growth. Associations of CK20 expression with morphological features and molecular markers were analyzed.

RESULTS:

CK20(+) PDA (n=91) was associated with more advanced disease stage and unfavorable prognosis compared with CK20(-) PDA (n=65). Pathologically, CK20(+) PDA was significantly associated with p53 overexpression, Por2, abundant fibrous stroma, and stepwise de-differentiation, while CK20(-) PDA was significantly associated with mismatch repair deficiency, Por1, sparse fibrous stroma, and de novo histogenesis.

CONCLUSION:

CK20 expression in PDA is closely associated with invasive histological features, providing prognostic significance, and may also point to a specific histogenetic pathway.

• Authors: Yasuo Imai, Hidetsugu Yamagishi, Kazunori Fukuda, Takuya Okamura, Yuko Ono, Shinichi Ban, Tohru Inoue, Yoshihiko Ueda
• Journal: Anticancer research (Anticancer Res) Vol. 34 Issue 1 Pg. 159-67 (Jan 2014) ISSN: 1791-7530 [Electronic] Greece
• PMID: 24403457 (Publication Type: Journal Article)

Chemical References

• Biomarkers, Tumor
• Keratin-20

Topics

• Adenocarcinoma (metabolism, mortality, pathology)
• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Cell Differentiation
• Colorectal Neoplasms (metabolism, mortality, pathology)
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Keratin-20 (metabolism)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Staging
• Phenotype
• Prognosis
• Survival Rate