Percutaneous image-guided cryoablation in inoperable extra-abdominal desmoid tumors: a study of tolerability and efficacy.

Abstract

OBJECTIVE:

To determine the tolerability, effectiveness and outcomes of percutaneous image-guided cryoablation on inoperable extra-abdominal desmoid tumors.

METHODS:

Between 2011 and 2012, 13 patients (mean age 39.3 years, range 15-74) with inoperable extra-abdominal desmoid tumors were consecutively treated with cryoablation (17 tumors treated in 17 procedures), including two patients with Gardner syndrome and nine recurrences after surgery. Disease-free survival (DFS) and local control based on RECIST criteria were calculated on prospective clinical and imaging follow-up until 2013.

RESULTS:

Cryoablation was performed under ultrasound (n = 8), computed tomography (n = 1), or combined (n = 8) guidance, and under general (n = 15) or local (n = 2) anesthesia. A major complication was observed in one session (5.8%). Mean follow-up was 11.3 months (6-27 months). Among all the patients treated, eight patients (47%) presented residual tumors on the first magnetic resonance follow-up, which were asymptomatic. The DFS rate was stable at 82.3% (95% confidence interval 0.55-0.94) at 6, 12, and 24 months. The local tumor progression rate was 0% at 6, 12, and 24 months. Two patients (12%) presented an in situ recurrence.

CONCLUSIONS:

Despite high rates of partial ablation, percutaneous image-guided cryoablation appears to be safe and effective for local control for patients with inoperable extra-abdominal desmoid tumors.

• Authors: M Havez, N Lippa, S Al-Ammari, M Kind, E Stoeckle, A Italiano, A Gangi, O Hauger, F Cornelis
• Journal: Cardiovascular and interventional radiology (Cardiovasc Intervent Radiol) Vol. 37 Issue 6 Pg. 1500-6 (Dec 2014) ISSN: 1432-086X [Electronic] United States
• PMID: 24402645 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Cryosurgery (methods)
• Female
• Fibromatosis, Abdominal (surgery)
• Gardner Syndrome (surgery)
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Radiography, Interventional
• Treatment Outcome
• Ultrasonography, Interventional