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[Immunobiological analysis of isolated subunits of influenza virus hemagglutinin].

Abstract
The immunogenic properties of isolated subunits of influenza A/FM/1/47 (H1N1) virus hemagglutinin were studied. The antihemagglutinating serum was tested by the CFT, HI, competitive solid-phase radioimmunoassay, and biological neutralization test. The antiserum was found to contain populations of antibodies to the three main antigenic determinants of hemagglutinin identical to the determinants of the intact virion, as well as antibodies to the antigenic components of host cells. The antiserum to hemagglutinin as well as monospecific antibodies to individual antigenic determinants of hemagglutinin exhibited a high virus-neutralizing activity for the homologous virus.
AuthorsT V Ignat'eva, E I Isaeva, Z I Rovnova
JournalVoprosy virusologii (Vopr Virusol) 1987 Mar-Apr Vol. 32 Issue 2 Pg. 151-6 ISSN: 0507-4088 [Print] Russia (Federation)
Vernacular TitleImmunobiologicheskiĭ analiz izolirovannykh sub''edinits gemaggliutinina virusa grippa.
PMID2440184 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Antibodies, Viral
  • Antigens, Surface
  • Epitopes
  • Hemagglutinins, Viral
  • Immune Sera
Topics
  • Animals
  • Antibodies, Viral (analysis)
  • Antibody Specificity
  • Antigen-Antibody Reactions
  • Antigens, Surface (analysis, immunology, isolation & purification)
  • Epitopes (immunology)
  • Hemagglutinins, Viral (analysis, immunology, isolation & purification)
  • Immune Sera (immunology)
  • Influenza A virus (immunology)
  • Neutralization Tests
  • Rabbits

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