HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Inhibitory effect of caffeine on 5-azacytidine-induced digital malformations in the rat.

Abstract
The effect of caffeine on 5-azacytidine (5-AC)-induced digital malformations in rat fetuses was investigated. Caffeine suppressed all types of digital defects in the fore- and hindlimbs except for syndactyly induced by 1.0 mg/kg of 5-AC; it was still effective when administered 24 hours after 5-AC treatment. However, fetal mortality increased as the frequency of malformations decreased. While the malformation results support the view that caffeine inhibits the processes leading to malformation expression, the relation between its suppressive effect on malformations and its enhancing effect on fetal mortality is unclear.
AuthorsA Kurishita, T Ihara
JournalTeratology (Teratology) Vol. 35 Issue 2 Pg. 247-52 (Apr 1987) ISSN: 0040-3709 [Print] United States
PMID2440123 (Publication Type: Journal Article)
Chemical References
  • Caffeine
  • Azacitidine
Topics
  • Abnormalities, Drug-Induced (etiology)
  • Animals
  • Azacitidine (antagonists & inhibitors, toxicity)
  • Caffeine (pharmacology)
  • Dose-Response Relationship, Drug
  • Female
  • Fetal Death (chemically induced)
  • Limb Deformities, Congenital
  • Methylation
  • Pregnancy
  • Rats

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: