Abstract |
Dodonaea polyandra is a medicinal plant used traditionally by the Kuuku I'yu (Northern Kaanju) indigenous people of Cape York Peninsula, Australia. The most potent of the diterpenoids previously identified from this plant, polyandric acid A (1), has been examined for inhibition of pro-inflammatory cytokine production and other inflammatory mediators using well-established acute and chronic mouse ear edema models and in vitro cellular models. Topical application of 1 significantly inhibited interleukin-1β production in mouse ear tissue in an acute model. In a chronic skin inflammation model, a marked reduction in ear thickness, associated with significant reduction in myeloperoxidase accumulation, was observed. Treatment of primary neonatal human keratinocytes with 1 followed by activation with phorbol ester/ ionomycin showed a significant reduction in IL-6 secretion. The present study provides evidence that the anti-inflammatory properties of 1 are due to inhibition of pro-inflammatory cytokines associated with skin inflammation and may be useful in applications for skin inflammatory conditions including psoriasis and dermatitis.
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Authors | Bradley S Simpson, Xianling Luo, Maurizio Costabile, Gillian E Caughey, Jiping Wang, David J Claudie, Ross A McKinnon, Susan J Semple |
Journal | Journal of natural products
(J Nat Prod)
Vol. 77
Issue 1
Pg. 85-91
(Jan 24 2014)
ISSN: 1520-6025 [Electronic] United States |
PMID | 24400858
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cytokines
- Diterpenes, Clerodane
- Interleukin-1beta
- Interleukin-6
- Lipopolysaccharides
- Tumor Necrosis Factor-alpha
- polyandric acid A
- Nitric Oxide
- Peroxidase
- Tetradecanoylphorbol Acetate
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Topics |
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
(blood, chemistry, isolation & purification, pharmacology)
- Australia
- Cytokines
(drug effects, metabolism)
- Disease Models, Animal
- Diterpenes, Clerodane
(blood, chemistry, isolation & purification, pharmacology)
- Ear
(pathology)
- Edema
(chemically induced, drug therapy)
- Interleukin-1beta
(antagonists & inhibitors)
- Interleukin-6
(analysis)
- Lipopolysaccharides
(pharmacology)
- Macrophages
(drug effects)
- Mice
- Mice, Inbred BALB C
- Molecular Structure
- Nitric Oxide
(biosynthesis)
- Peroxidase
(analysis, metabolism)
- Plants, Medicinal
(chemistry)
- Psoriasis
(drug therapy)
- Sapindaceae
(chemistry)
- Skin
(drug effects, pathology)
- Tetradecanoylphorbol Acetate
(pharmacology)
- Tumor Necrosis Factor-alpha
(analysis)
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