[Synthesis of aminopropylaminoderivatives of betulinic and oleanolic acids].

Abstract

On the basis of betulinic and oleanolic acids triterpenoids with different with different amine fragments: (3-aminopropoxy)-, 3-acetyl-(3-aminopropyl)amino-, 6-[bis(3-aminopropyl)amino]hexylamino-, (3-aminopropyl)-4-aminosulfonyl-4-phenylamino- at positions C3 and C28 were synthesized. It is shown that betulonic acid amide with 4,4'-diaminodiphenylsulfonic substituent don't render antitumor effect in mice with transplantable Lewis lung carcinoma, but possess significant anti-inflammatory activity.

• Authors: G V Giniiatullina, O B Kazakova, N I Medvedeva, I V Sorokina, N A Zhukova, T G Tolstikova, G A Tolstikov
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) 2013 May-Jun Vol. 39 Issue 3 Pg. 369-77 ISSN: 0132-3423 [Print] Russia (Federation)
• PMID: 24397036 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Antineoplastic Agents
• Pentacyclic Triterpenes
• Triterpenes
• oleanonic acid
• Oleanolic Acid
• Histamine
• Betulinic Acid

Topics

• Animals
• Anti-Inflammatory Agents (administration & dosage, chemical synthesis, chemistry)
• Antineoplastic Agents (administration & dosage, chemical synthesis, chemistry)
• Carcinoma, Lewis Lung (drug therapy, pathology)
• Histamine (toxicity)
• Humans
• Inflammation (chemically induced, drug therapy)
• Mice
• Oleanolic Acid (administration & dosage, chemical synthesis, chemistry)
• Pentacyclic Triterpenes
• Triterpenes (chemical synthesis, chemistry)
• Betulinic Acid