Abstract | BACKGROUND: OBJECTIVES: MATERIALS AND METHODS: TWENTY FOUR RABBITS WERE ASSIGNED TO FOUR GROUPS INCLUDING: control, noise plus saline, noise plus NAC administration (325 mg/kg body weight by intraperitoneal injection (IP), three days before exposure to noise and three days after noise exposure), and NAC alone. Auditory brain stem response (ABR) threshold was measured before exposure and one hour and 14 days after exposure. RESULTS: The saline plus noise group had on average a 49 decibel (dB) temporary threshold shift (TTS) and 23.9 dB permanent threshold shift (PTS) at the studied frequencies, while rabbits in the NAC administration plus noise group had a 31.5 dB TTS and 10.7 dB PTS averaged across the frequencies. CONCLUSIONS: Administration of NAC can provide appropriate protection against acoustic trauma-induced hearing loss in rabbits at all studied frequencies.
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Authors | Masoud Motalebi Kashani, Hamidreza Saberi, Mitra Hannani |
Journal | Archives of trauma research
(Arch Trauma Res)
Vol. 1
Issue 4
Pg. 145-50
( 2013)
ISSN: 2251-953X [Print] Netherlands |
PMID | 24396768
(Publication Type: Journal Article)
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