Polyglandular autoimmune syndrome is defined as multiple endocrine gland insufficiencies accompanied by
autoimmune diseases of the endocrine and nonendocrine system. After Schmidt introduced a case of nontuberculosis adrenal gland dysfunction with
thyroiditis in 1926, Neufeld defined polyglandular autoimmune syndrome by I, II, and III subtypes in 1980 by their presentation of occurrence age, heredity methods, relationship with
human leukocyte antigen, and accompanying diseases. We report a case of a 32-year-old female with polyglandular autoimmune syndrome III accompanied by
type 1 diabetes mellitus that was treated with
insulin (36 units per day) for 11 years. She had
insulin deficiency and
Hashimoto thyroiditis as an autoimmune disorder. In addition, she had several features similar to Albright's hereditary osteodystrophy including short stature, truncal
obesity, round face, short neck, low intelligence (full IQ 84), and decreased memory. Although Albright's hereditary osteodystrophy is morphological evidence of
pseudohypoparathyroidism or
pseudopseudohypoparathyroidism, she had primary
hypoparathyroidism on laboratory results. Here, we report a case of polyglandular autoimmune syndrome III with
type 1 diabetes mellitus,
autoimmune thyroiditis, and primary
hypoparathyroidism, accompanied by clinical features similar to Albright's hereditary osteodystrophy.