Trikatu, an herbal compound as immunomodulatory and anti-inflammatory agent in the treatment of rheumatoid arthritis--an experimental study.

Abstract

In the present study, trikatu, an herbal compound was evaluated for its immunomodulatory and anti-inflammatory properties with reference to cell mediated immune responses (delayed type hypersensitivity reaction), humoral immune response (haemagglutination titer and plaque forming assay), macrophage phagocytic index, circulating immune complex and inflammatory mediators in rats. For comparison purposes, indomethacin was used as a reference drug for anti-inflammatory studies. The results obtained in our study showed a significant decrease in cell mediated immune responses, humoral immune responses (haemagglutination titre and plaque forming assay) and macrophage phagocytic index in trikatu treated rats (1000 mg/kg/b.wt.) compared to control animals implying its immunosuppressive property. In addition, significant anti-inflammatory effects were observed in trikatu treated adjuvant induced arthritic rats by a reduction in the levels of circulating immune complexes and inflammatory mediators (TNF-alpha and Interleukin-1beta). Thus, in conclusion, our data suggest that trikatu could be considered as a potential anti-inflammatory agent for treating autoimmune inflammatory disorders like rheumatoid arthritis with immunosuppressive property.

• Authors: Vachana Murunikkara, Mahaboobkhan Rasool
• Journal: Cellular immunology (Cell Immunol) Vol. 287 Issue 1 Pg. 62-8 (Jan 2014) ISSN: 1090-2163 [Electronic] Netherlands
• PMID: 24394943 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Alkenes
• Anti-Inflammatory Agents, Non-Steroidal
• Inflammation Mediators
• Interleukin-1beta
• Piperidines
• Tumor Necrosis Factor-alpha
• trikatu
• Indomethacin

Topics

• Alkenes (administration & dosage)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Arthritis, Rheumatoid (therapy)
• Cells, Cultured
• Female
• Hemolytic Plaque Technique
• Herbal Medicine
• Hypersensitivity, Delayed (therapy)
• Immunity, Cellular (drug effects)
• Immunity, Humoral (drug effects)
• Immunomodulation
• Indomethacin (administration & dosage)
• Inflammation Mediators (metabolism)
• Interleukin-1beta (metabolism)
• Macrophages (immunology)
• Phagocytosis (drug effects)
• Piperidines (administration & dosage)
• Rats
• Rats, Wistar
• Tumor Necrosis Factor-alpha (metabolism)