Abstract | CONTEXT: PATIENT: RESULTS: Normalization of testosterone levels and a stable low sperm concentration (0.5 mill/ml) with good sperm motility (85% A+B progressive) were achieved within 21 months of treatment. Despite persisting TARTs, while receiving treatment, the patient successfully impregnated his wife twice, the latter impregnation leading to the birth of a healthy girl. CONCLUSIONS: TARTs in unrecognized (simple virilizing) CAH may lead to unnecessary orchiectomy. In hypogonadotropic, azoospermic CAH, a combined treatment with oral corticosteroids and subcutaneously administered hCG and FSH can successfully restore testicular testosterone production and fertility, even if only one hypoplastic and atrophic testis with adrenal rest tumors is present.
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Authors | Julia Rohayem, Frank Tüttelmann, Con Mallidis, Eberhard Nieschlag, Sabine Kliesch, Michael Zitzmann |
Journal | European journal of endocrinology
(Eur J Endocrinol)
Vol. 170
Issue 4
Pg. K11-7
(Apr 2014)
ISSN: 1479-683X [Electronic] England |
PMID | 24394723
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Chorionic Gonadotropin
- Reproductive Control Agents
- Menotropins
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Topics |
- Adrenal Hyperplasia, Congenital
(complications)
- Adrenal Rest Tumor
(complications, surgery)
- Adult
- Azoospermia
(drug therapy, etiology)
- Chorionic Gonadotropin
(therapeutic use)
- Hormone Replacement Therapy
(methods)
- Humans
- Hypogonadism
- Male
- Menotropins
(therapeutic use)
- Orchiectomy
- Reproductive Control Agents
(therapeutic use)
- Testicular Neoplasms
(complications, surgery)
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