[A case of advanced gastric cancer with carcinomatous lymphangitis of the lung treated with docetaxel and S-1 combination chemotherapy].

Abstract

A 67-year-old woman with complaints of cough and dyspnea was admitted; her chest radiographs and computed tomography (CT) scans revealed pulmonary carcinomatous lymphangitis. Endoscopic examination revealed advanced gastric cancer and the patient was treated with a combination of 40 mg/m2 docetaxel, administered on day 1, and S-1 100 mg/body/day, administered for 14 days followed by a 7-day interval, as 1 course despite her performance status( PS) being grade 3. After 2 courses of chemotherapy, CT showed that the carcinomatous lymphangitis had improved, and the patient was discharged with PS of grade 0. We report that combination chemotherapy with docetaxel and S-1 might be effective for the treatment of advanced gastric cancer with carcinomatous lymphangitis of the lung in patients with a poor systemic condition.

• Authors: Eiko Okamoto, Kentaro Takagi, Atsushi Tamura, Mayumi Kondo, Satoko Hanada, Haruyasu Sakuranaka, Junichi Ochi, Michiko Tanaka, Shikofumi Tei, Masahiko Ichioka, Takao Shibayama
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 12 Pg. 2247-9 (Nov 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 24394074 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Drug Combinations
• Taxoids
• S 1 (combination)
• Tegafur
• Docetaxel
• Oxonic Acid

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Docetaxel
• Drug Combinations
• Fatal Outcome
• Female
• Humans
• Lung Neoplasms (drug therapy, secondary)
• Lymphangitis (etiology)
• Oxonic Acid (administration & dosage)
• Stomach Neoplasms (drug therapy, pathology)
• Taxoids (administration & dosage)
• Tegafur (administration & dosage)