[Neoadjuvant chemoradiotherapy with capecitabine and oxaliplatin for the treatment of locally advanced lower rectal cancer].

Abstract

Chemoradiotherapy before surgical treatment of locally advanced lower rectal cancer is currently uncommon in Japan. We have treated 5 patients with T3 and/or N1 and 2 patients with rectal cancer using chemoradiotherapy including capecitabine and oxaliplatin( XELOX). The treatment consisted of concomitant administration of radiotherapy( 45 Gy/25 Fr), capecitabine (2,000 mg/m2/day; 2 weeks followed by 1 week off), and XELOX (2 courses). Surgery was performed 1 month after the final dose of chemotherapy was administered. The adverse events of Grade greater than 2 observed were radiation dermatitis (n=3), peripheral neuropathy (n=1), and rash (n=1). Either laparoscopic abdominoperineal resection( n=4) or open low anterior resection( n=1) was performed for surgical treatment. Histopathological regression grading revealed Grade 1a (n=1) and Grade 2 (n=4). The combined therapy resulted in downstaging in all patients. Preoperative chemoradiotherapy followed by XELOX might be effective for the treatment of locally advanced lower rectal cancer.

• Authors: Kohei Murata, Shu Okamura, Hirofumi Okubo, Yoshiyuki Owada, Takahiko Nishigaki, Yuma Wada, Ryo Kato, Shunichiro Makino, Tomohira Takeoka, Kazuyuki Okada, Nariaki Fukuchi, Chikara Ebisui, Masakatsu Kinuta
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 40 Issue 12 Pg. 2020-2 (Nov 2013) ISSN: 0385-0684 [Print] Japan
• PMID: 24393999 (Publication Type: Journal Article)

Chemical References

• Oxaloacetates
• Deoxycytidine
• Capecitabine
• Fluorouracil

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (administration & dosage, therapeutic use)
• Capecitabine
• Chemoradiotherapy
• Deoxycytidine (administration & dosage, analogs & derivatives)
• Female
• Fluorouracil (administration & dosage, analogs & derivatives)
• Humans
• Male
• Middle Aged
• Neoadjuvant Therapy
• Neoplasm Grading
• Neoplasm Staging
• Oxaloacetates
• Rectal Neoplasms (pathology, surgery, therapy)