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Multimodal SPION-CREKA peptide based agents for molecular imaging of microthrombus in a rat myocardial ischemia-reperfusion model.

Abstract
Microthrombosis plays a key role in many cardiovascular diseases. Although it is not difficult to localize thrombus within large or middle-sized vessels, the noninvasive diagnostic regimen for the detection of microthrombus remains scarce. Here we developed a nanoagent by conjucting superparamagnetic iron-oxide nanoparticle with fluorophore and a targeting element, CREKA, a peptide with special affinity for fibrin. In a rat model of myocardial ischemia-reperfusion (MI/R), the multimodal nanoagents were readily and selectively accumulated within microthrombosis, which was detectable by both magnetic resonance and optical imaging modalities. The fibrin-targeted nanoagent could be expected to have utility not only in molecular imaging of fibrin, understanding the mechanisms of microcirculation disorders, but also in targeted therapy with fibrinolytic agents.
AuthorsYanan Song, Zheyong Huang, Jianfeng Xu, Daoyuan Ren, Yu Wang, Xinde Zheng, Yunli Shen, Lili Wang, Hongxiang Gao, Jiayun Hou, Zhiqing Pang, Juying Qian, Junbo Ge
JournalBiomaterials (Biomaterials) Vol. 35 Issue 9 Pg. 2961-70 (Mar 2014) ISSN: 1878-5905 [Electronic] Netherlands
PMID24393265 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Dextrans
  • Magnetite Nanoparticles
  • Oligopeptides
  • cysteinyl-arginyl-glutamyl-lysyl-alanyl
  • ferumoxides
Topics
  • Animals
  • Blood Coagulation (drug effects)
  • Blood Platelets (drug effects, pathology, ultrastructure)
  • Dextrans
  • Disease Models, Animal
  • Humans
  • Magnetite Nanoparticles
  • Male
  • Microscopy, Fluorescence
  • Molecular Imaging (methods)
  • Multimodal Imaging (methods)
  • Myocardial Reperfusion Injury (complications, diagnosis)
  • Nanoparticles (chemistry, ultrastructure)
  • Oligopeptides (pharmacology)
  • Optical Imaging
  • Particle Size
  • Rats
  • Rats, Sprague-Dawley
  • Static Electricity
  • Thrombosis (complications, diagnosis)

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