Abstract | BACKGROUND: METHODS: One day before unilateral ureteral obstruction (UUO) performed in C57BL/6 mice, oleanolic acid treatment was initiated and was continued until 3 and 7 days after UUO. Renal inflammation and fibrosis, markers of oxidative stress, and changes in Nrf2 expression were subsequently evaluated. RESULTS: CONCLUSIONS: These results suggest that oleanolic acid may exert beneficial effects on renal fibrosis by increasing nuclear translocation of Nrf2 and subsequently reducing renal oxidative stress.
|
Authors | Sungjin Chung, Hye Eun Yoon, Soo Jeong Kim, Sung Jun Kim, Eun Sil Koh, Yu Ah Hong, Cheol Whee Park, Yoon Sik Chang, Seok Joon Shin |
Journal | Nutrition & metabolism
(Nutr Metab (Lond))
Vol. 11
Issue 1
Pg. 2
(Jan 06 2014)
ISSN: 1743-7075 [Print] England |
PMID | 24393202
(Publication Type: Journal Article)
|