Sodium channels, inherited epilepsy, and antiepileptic drugs.

Voltage-gated sodium channels initiate action potentials in brain neurons, mutations in sodium channels cause inherited forms of epilepsy, and sodium channel blockers-along with other classes of drugs-are used in therapy of epilepsy. A mammalian voltage-gated sodium channel is a complex containing a large, pore-forming α subunit and one or two smaller β subunits. Extensive structure-function studies have revealed many aspects of the molecular basis for sodium channel structure, and X-ray crystallography of ancestral bacterial sodium channels has given insight into their three-dimensional structure. Mutations in sodium channel α and β subunits are responsible for genetic epilepsy syndromes with a wide range of severity, including generalized epilepsy with febrile seizures plus (GEFS+), Dravet syndrome, and benign familial neonatal-infantile seizures. These seizure syndromes are treated with antiepileptic drugs that offer differing degrees of success. The recent advances in understanding of disease mechanisms and sodium channel structure promise to yield improved therapeutic approaches.
AuthorsWilliam A Catterall
JournalAnnual review of pharmacology and toxicology (Annu Rev Pharmacol Toxicol) Vol. 54 Pg. 317-38 ( 2014) ISSN: 1545-4304 [Electronic] United States
PMID24392695 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)
Chemical References
  • Anticonvulsants
  • Voltage-Gated Sodium Channel Blockers
  • Voltage-Gated Sodium Channels
  • Animals
  • Anticonvulsants (pharmacology)
  • Crystallography, X-Ray
  • Disease Models, Animal
  • Epilepsies, Myoclonic (drug therapy, genetics)
  • Humans
  • Molecular Targeted Therapy
  • Mutation
  • Neurons (drug effects, metabolism)
  • Seizures, Febrile (drug therapy, genetics)
  • Voltage-Gated Sodium Channel Blockers (pharmacology)
  • Voltage-Gated Sodium Channels (chemistry, genetics)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: