Abstract |
Adult rheumatoid arthritis (RA) is a very heterogeneous disease that is associated with HLA-antigens, although no absolute association has been found with any particular HLA type. Forty-one seropositive RA patients have been studied with a local monoclonal antibody named X1 21.4 (9w940), strongly associated with HLA-DRI, DR4, Drw10 antigens, to verify a possible correlation with the disease. The results obtained have also been compared with the data reported on MC1, a serologically defined determinant correlated with RA. X1 21.4 monoclonal antibody appears to be associated with the disease and it could identify one epitope involved in the susceptibility to RA.
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Authors | S Cappellacci, T Tuzi, M C Mazzilli, M Morellini, P Lulli, M Galeazzi |
Journal | Clinical and experimental rheumatology
(Clin Exp Rheumatol)
1987 Jan-Mar
Vol. 5
Issue 1
Pg. 63-6
ISSN: 0392-856X [Print] Italy |
PMID | 2439246
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Monoclonal
- Epitopes
- HLA Antigens
- HLA-DR Antigens
- HLA-DR1 Antigen
- HLA-DR4 Antigen
- HLA-DRw10
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Topics |
- Adult
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
(immunology)
- Epitopes
- HLA Antigens
- HLA-DR Antigens
- HLA-DR1 Antigen
- HLA-DR4 Antigen
- Humans
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