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HLA antigens and adult rheumatoid arthritis: a study with a monoclonal antibody.

Abstract
Adult rheumatoid arthritis (RA) is a very heterogeneous disease that is associated with HLA-antigens, although no absolute association has been found with any particular HLA type. Forty-one seropositive RA patients have been studied with a local monoclonal antibody named X1 21.4 (9w940), strongly associated with HLA-DRI, DR4, Drw10 antigens, to verify a possible correlation with the disease. The results obtained have also been compared with the data reported on MC1, a serologically defined determinant correlated with RA. X1 21.4 monoclonal antibody appears to be associated with the disease and it could identify one epitope involved in the susceptibility to RA.
AuthorsS Cappellacci, T Tuzi, M C Mazzilli, M Morellini, P Lulli, M Galeazzi
JournalClinical and experimental rheumatology (Clin Exp Rheumatol) 1987 Jan-Mar Vol. 5 Issue 1 Pg. 63-6 ISSN: 0392-856X [Print] Italy
PMID2439246 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibodies, Monoclonal
  • Epitopes
  • HLA Antigens
  • HLA-DR Antigens
  • HLA-DR1 Antigen
  • HLA-DR4 Antigen
  • HLA-DRw10
Topics
  • Adult
  • Antibodies, Monoclonal
  • Arthritis, Rheumatoid (immunology)
  • Epitopes
  • HLA Antigens
  • HLA-DR Antigens
  • HLA-DR1 Antigen
  • HLA-DR4 Antigen
  • Humans

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