Abstract | BACKGROUND: Rheumatic mitral stenosis (MS) causes stagnation of blood flow, leading to thrombus formation in the left atrium (LA), which may lead to systemic thromboembolic complications. We compared alterations in circulating levels of pro-/ anti-oxidants and markers of inflammation in patients of severe rheumatic MS with and without LA thrombus and studied their predictive power to detect the presence of LA thrombus in patients with rheumatic MS. MATERIAL AND METHODS: RESULTS: Levels of plasma MDA, protein carbonyl and total oxidant status were significantly elevated, whilst the total antioxidant status levels were significantly lowered, in Group 1, as compared with Group 2. hs-CRP, TSA and PBSA levels showed a significant rise in Group 1 patients, as compared with Group 2. CONCLUSION: Our results suggest that circulating levels of MDA, protein carbonyl and PBSA were independent predictors of occurrence of LA thrombus in patients with rheumatic MS.
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Authors | Vinay Kumar Pulimamidi, Vengatesan Murugesan, Medha Rajappa, Santhosh Satheesh, Kottenyen Thazhath Harichandrakumar |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 7
Issue 11
Pg. 2445-8
(Nov 2013)
ISSN: 2249-782X [Print] India |
PMID | 24392368
(Publication Type: Journal Article)
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