Abstract | BACKGROUND: METHODS AND FINDINGS: In vitro, phytol reduced the motor activity of worms, caused their death and confocal laser scanning microscopy analysis showed extensive tegumental alterations in a concentration-dependent manner (50 to 100 µg/mL). Additionally, phytol at sublethal doses (25 µg/mL) reduced the number of Schistosoma mansoni eggs. In vivo, a single dose of phytol (40 mg/kg) administered orally to mice infected with adult S. mansoni resulted in total and female worm burden reductions of 51.2% and 70.3%, respectively. Moreover, phytol reduced the number of eggs in faeces (76.6%) and the frequency of immature eggs (oogram pattern) was significantly reduced. The oogram also showed increases in the proportion of dead eggs. Confocal microcopy studies revealed tegumental damage in adult S. mansoni recovered from mice, especially in female worms. CONCLUSIONS:
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Authors | Josué de Moraes, Rosimeire N de Oliveira, Jéssica P Costa, Antonio L G Junior, Damião P de Sousa, Rivelilson M Freitas, Silmara M Allegretti, Pedro L S Pinto |
Journal | PLoS neglected tropical diseases
(PLoS Negl Trop Dis)
Vol. 8
Issue 1
Pg. e2617
( 2014)
ISSN: 1935-2735 [Electronic] United States |
PMID | 24392173
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Administration, Oral
- Animals
- Anthelmintics
(pharmacology, therapeutic use)
- Disease Models, Animal
- Female
- Locomotion
(drug effects)
- Mice
- Mice, Inbred BALB C
- Parasite Load
- Parasitic Sensitivity Tests
- Phytol
(pharmacology, therapeutic use)
- Schistosoma mansoni
(drug effects)
- Schistosomiasis mansoni
(drug therapy)
- Survival Analysis
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