Assessment of brain damage and plasticity in the visual system due to early occipital lesion: comparison of FDG-PET with diffusion MRI tractography.

Abstract

PURPOSE:

To determine the relation between glucose metabolic changes of the primary visual cortex, structural abnormalities of the corresponding visual tracts, and visual symptoms in children with Sturge-Weber syndrome (SWS).

MATERIALS AND METHODS:

In 10 children with unilateral SWS (ages 1.5-5.5 years), a region-of-interest analysis was applied in the bilateral medial occipital cortex on positron emission tomography (PET) and used to track diffusion-weighted imaging (DWI) streamlines corresponding to the central visual pathway. Normalized streamline volumes of individual SWS patients were compared with values from age-matched control groups as well as correlated with normalized glucose uptakes and visual field deficit.

RESULTS:

Lower glucose uptake and lower corresponding streamline volumes were detected in the affected occipital lobe in 9/10 patients, as compared to the contralateral side. Seven of these 9 patients had visual field deficit and normal or decreased streamline volumes on the unaffected side. The two other children had no visual symptoms and showed high contralateral visual streamline volumes. There was a positive correlation between the normalized ratios on DWI and PET, indicating that lower glucose metabolism was associated with lower streamline volume in the affected hemisphere (R = 0.70, P = 0.024).

CONCLUSION:

We demonstrated that 18F-flurodeoxyglucose (FDG)-PET combined with DWI tractography can detect both brain damage on the side of the lesion and contralateral plasticity in children with early occipital lesions.

• Authors: Jeong-won Jeong, Vijay N Tiwari, Joseph Shin, Harry T Chugani, Csaba Juhász
• Journal: Journal of magnetic resonance imaging : JMRI (J Magn Reson Imaging) Vol. 41 Issue 2 Pg. 431-8 (Feb 2015) ISSN: 1522-2586 [Electronic] United States
• PMID: 24391057 (Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural)
• Copyright: © 2014 Wiley Periodicals, Inc.

Chemical References

• Radiopharmaceuticals
• Fluorodeoxyglucose F18

Topics

• Adolescent
• Case-Control Studies
• Child
• Child, Preschool
• Diffusion Tensor Imaging (methods)
• Female
• Fluorodeoxyglucose F18
• Humans
• Infant
• Longitudinal Studies
• Magnetic Resonance Imaging (methods)
• Male
• Positron-Emission Tomography (methods)
• Prospective Studies
• Radiopharmaceuticals
• Sturge-Weber Syndrome (pathology)
• Visual Cortex (pathology)