Vascular endothelial growth factor +936C/T polymorphism and breast cancer risk: a meta-analysis of 13 case-control studies.

Abstract

The association between vascular endothelial growth factor (VEGF) +936C/T polymorphism and breast cancer risk has been widely reported, but results were inconsistent. In order to derive a more precise estimation of the relationship, a meta-analysis was performed. Eligible articles were identified through search of databases including PubMed, Embase, and Chinese Biomedical Literature Database (CBM). The association between the VEGF +936C/T polymorphism and breast cancer risk was conducted by odds ratios (ORs) and 95% confidence intervals (95% CIs). Finally, a total of 13 studies with 6,879 cases and 7,219 controls were included in our meta-analysis. Overall, a significant association was found between VEGF +936C/T polymorphisms and the risk of breast cancer in overall populations under five models (T vs. C: OR = 0.83, 95% CI = 0.73-0.94, P = 0.002; TT vs. CC: OR = 0.74, 95% CI = 0.61-0.91, P = 0.004, Fig. 1a; TC vs. CC: OR = 0.83, 95% CI = 0.71-0.96, P = 0.014; TT vs.

CC/CT:

OR = 0.77, 95% CI = 0.62-0.94, P = 0.010; TT/TC vs. CC: OR = 0.82, 95% CI = 0.72-0.95, P = 0.006). In the subgroup analysis by ethnicity, there were also significant associations found between VEGF +936C/T polymorphism and breast cancer risk in Asians and Caucasians. In conclusion, the results of our meta-analysis suggest that the VEGF +936C/T polymorphism is significantly associated with breast cancer development and the VEGF 936T allele carriers may be associated with decreased breast cancer risk.

• Authors: Yulan Yan, Hongjie Liang, Taijie Li, Shihui Guo, Meng Li, Shan Li, Xue Qin
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 35 Issue 3 Pg. 2687-92 (Mar 2014) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 24390659 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• VEGFA protein, human
• Vascular Endothelial Growth Factor A

Topics

• Breast Neoplasms (genetics)
• Case-Control Studies
• Female
• Genetic Predisposition to Disease (genetics)
• Humans
• Odds Ratio
• Polymorphism, Single Nucleotide (genetics)
• Vascular Endothelial Growth Factor A (genetics)