Abstract |
We tested whether long-term administration of voglibose (VO) prevents diet induced obesity in addition to hypoglycemic effects in high fat fed mice and further investigated the underlying mechanisms by which voglibose exerts its weight lowering effect. Male C57BL/6 mice were fed ad libitum for 12 weeks with the control diet (CTL), high-fat diet (HFD) or the HFD with VO supplementations. Blood lipid profile, plasma leptin levels and hepatic triglyceride content, as well as expressions of genes involved in appetite and mitochondrial function were examined. The results showed that VO significantly reduced body weight, fat mass and energy intakes in high fat fed mice. VO showed improved metabolic profiles including blood glucose, triglyceride and free fatty acid. Elevated levels of plasma leptin in HFD were significantly reduced with the VO, furthermore, VO modulated the hypothalamic expressions of leptin receptors and appetite related genes. VO showed the upregulated expressions of PGC-1 in the liver and epididymal adipose tissue. In conclusion, VO may exert antiobesity properties through reductions in energy intake and improvement in mitochondrial function, indicating that VO has potential therapeutic use in patients with obesity, type 2 diabetes, and related complications.
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Authors | Hyun Ju Do, Taeon Jin, Ji Hyung Chung, Ji Won Hwang, Min-Jeong Shin |
Journal | Biochemical and biophysical research communications
(Biochem Biophys Res Commun)
Vol. 443
Issue 3
Pg. 1110-7
(Jan 17 2014)
ISSN: 1090-2104 [Electronic] United States |
PMID | 24388987
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Agouti-Related Protein
- Agrp protein, mouse
- Glucose Transporter Type 4
- Insulin
- Leptin
- Nerve Tissue Proteins
- Neuropeptide Y
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Ppargc1a protein, mouse
- Receptors, Leptin
- Slc2a4 protein, mouse
- Transcription Factors
- Triglycerides
- cocaine- and amphetamine-regulated transcript protein
- Inositol
- Pro-Opiomelanocortin
- voglibose
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Topics |
- Adiposity
(drug effects, genetics)
- Agouti-Related Protein
(genetics, metabolism)
- Animals
- Appetite
(drug effects, genetics)
- Body Weight
(drug effects)
- Diet, High-Fat
- Energy Intake
(drug effects)
- Gene Expression Regulation
(drug effects)
- Glucose Transporter Type 4
(genetics, metabolism)
- Hypothalamus
(drug effects, metabolism, pathology)
- Inositol
(administration & dosage, analogs & derivatives, pharmacology)
- Insulin
(blood)
- Insulin Resistance
- Insulin-Secreting Cells
(drug effects, metabolism, pathology)
- Leptin
(blood)
- Liver
(drug effects, metabolism)
- Male
- Mice
- Mice, Obese
- Nerve Tissue Proteins
(genetics, metabolism)
- Neuropeptide Y
(genetics, metabolism)
- Organ Specificity
(drug effects, genetics)
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Pro-Opiomelanocortin
(metabolism)
- Receptors, Leptin
(genetics, metabolism)
- Transcription Factors
(genetics, metabolism)
- Triglycerides
(metabolism)
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