Impact on optical coherence tomographic coronary findings of fluvastatin alone versus fluvastatin + ezetimibe.

Abstract

Although lipid-lowering therapy with statin and ezetimibe has been reported to provide greater reduction in low-density lipoprotein cholesterol levels than statin monotherapy, the effect of supplemental therapy on plaque stabilization is yet to be fully elucidated. Cap thickness of fibroatheroma evaluated by optical coherence tomography (OCT) is a major determinant of vulnerable plaque. The primary objective of this study is to evaluate the effect of ezetimibe in addition to fluvastatin on the progression of coronary atherosclerotic plaque evaluated by OCT. Sixty-three patients with angina pectoris with intermediate, nonculprit, lipid-rich plaque lesions evaluated by OCT were enrolled. The patients were divided into 2 groups: ezetimibe (10 mg/day) + fluvastatin (30 mg/day), and fluvastatin (30 mg/day) alone, and serial OCT examinations were performed at baseline and 9-month follow-up. A total of 57 patients (ezetimibe + fluvastatin, n = 31; fluvastatin alone, n = 26) underwent serial OCT examinations. The change in low-density lipoprotein cholesterol level was significantly larger in the ezetimibe + fluvastatin group compared with fluvastatin-alone group (-34.0 ± 32.0 vs -8.3 ± 17.4 mg/dl, p <0.001). Fibrous cap thickness was significantly increased and the angle of the lipid plaque was significantly decreased in both groups. The change in the fibrous cap thickness was significantly greater in the ezetimibe + fluvastatin group (0.08 ± 0.08 mm vs 0.04 ± 0.06 mm, p <0.001). In conclusion, lipid-lowering therapy by ezetimibe + fluvastatin could increase the fibrous cap thickness of lipid-rich plaque compared with fluvastatin monotherapy.

• Authors: Maoto Habara, Kenya Nasu, Mitsuyasu Terashima, Euihong Ko, Daisuke Yokota, Tsuyoshi Ito, Tairo Kurita, Tomohiko Teramoto, Masashi Kimura, Yoshihisa Kinoshita, Etsuo Tsuchikane, Yasushi Asakura, Tetsuo Matsubara, Takahiko Suzuki
• Journal: The American journal of cardiology (Am J Cardiol) Vol. 113 Issue 4 Pg. 580-7 (Feb 15 2014) ISSN: 1879-1913 [Electronic] United States
• PMID: 24388622 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Anticholesteremic Agents
• Azetidines
• Cholesterol, LDL
• Fatty Acids, Monounsaturated
• Indoles
• Fluvastatin
• Ezetimibe

Topics

• Adult
• Aged
• Aged, 80 and over
• Anticholesteremic Agents (administration & dosage, therapeutic use)
• Azetidines (administration & dosage, therapeutic use)
• Cholesterol, LDL (blood)
• Coronary Vessels (pathology)
• Disease Progression
• Drug Therapy, Combination
• Ezetimibe
• Fatty Acids, Monounsaturated (administration & dosage, therapeutic use)
• Female
• Fluvastatin
• Follow-Up Studies
• Humans
• Indoles (administration & dosage, therapeutic use)
• Male
• Middle Aged
• Plaque, Atherosclerotic (blood, diagnosis, drug therapy)
• Prospective Studies
• Tomography, Optical Coherence (methods)