Diagnostic yield of fine needle aspiration biopsy in HIV-infected adults with suspected mycobacterial lymphadenitis.

Abstract

BACKGROUND:

Fine needle aspiration biopsy (FNAB) has been shown to be the diagnostic procedure of choice for superficial lymphadenitis in tuberculosis endemic regions.

METHODS:

We conducted a retrospective laboratory-based study to determine the bacteriological yield of clinically suspected mycobacterial tuberculous lymphadenitis following FNAB in adults, and specifically HIV-positive patients, to determine the need for the introduction of automated nucleic acid amplification tests (NAATs) such as the Xpert MTB/RIF assay as the initial diagnostic modality. RESULTS. A diagnostic yield of 80% was achieved, significantly higher in HIV-positive v. HIV-negative patients (84% v. 52%, respectively; p<0.001).

CONCLUSION:

The results justify using automated NAATs such as the Xpert MTB/RIF assay as the initial diagnostic modality to expedite management in HIV-infected patients.

• Authors: R Razack, M Louw, C A Wright
• Journal: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde (S Afr Med J) Vol. 104 Issue 1 Pg. 27-8 (Nov 20 2013) ISSN: 0256-9574 [Print] South Africa
• PMID: 24388082 (Publication Type: Journal Article)

Topics

• Adolescent
• Adult
• Aged
• Biopsy, Fine-Needle (methods)
• Female
• HIV Infections (complications)
• Humans
• Male
• Middle Aged
• Retrospective Studies
• Tuberculosis, Lymph Node (diagnosis, pathology)