Abstract | BACKGROUND: rs12979860 and rs8099917 interleukin-28B polymorphisms are associated with spontaneous or interferon-alpha induced hepatitis C clearance, "CC" and "TT" genotypes (respectively) being the most favourable. There are no data on the influence of interleukin-28B polymorphisms on hepatitis delta clearance in hepatitis B/D co-infected patients. AIMS: The present study explores the potential influence of both rs12979860 and rs8099917 polymorphisms on delta infection outcome. METHODS: Retrospective-longitudinal study on 55 European patients observed for at least 4 years, selected from a cohort of 439 subjects positive for hepatitis delta antibodies and hepatitis B core antibodies. The rate of spontaneous and interferon induced delta- RNA clearance was compared in interleukin-28B rs12979860 "CC" vs "non CC", and in rs8099917 "TT" vs "non TT" genotypes. RESULTS: Prevalence of rs12979860C allele was 60%, consistent with the reported prevalence in Italy (67%, p=0.128). No significant differences in spontaneous clearance rate were observed between rs12979860 "CC" and "non CC" genotypes (13.3% vs 7.5%, respectively, p=0.60), and between rs8099917 "TT" and "non-TT" genotypes (11.1 vs 7.1%, respectively, p=0.67). No differences were observed for interferon-induced delta- RNA clearance either. CONCLUSIONS: Our data suggest that interleukin-28B polymorphisms might not influence hepatitis delta clearance rate in either natural history or interferon-alpha response.
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Authors | Ubaldo Visco-Comandini, Daniele Lapa, Chiara Taibi, Claudio Angeletti, Maria Rosaria Capobianchi, Anna Rosa Garbuglia |
Journal | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
(Dig Liver Dis)
Vol. 46
Issue 4
Pg. 348-52
(Apr 2014)
ISSN: 1878-3562 [Electronic] Netherlands |
PMID | 24387833
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Published by Elsevier Ltd. |
Chemical References |
- Antiviral Agents
- Hepatitis Antibodies
- IFNL3 protein, human
- Interferon-alpha
- Interleukins
- RNA, Viral
- Interferons
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Topics |
- Adult
- Antiviral Agents
(therapeutic use)
- Cohort Studies
- Female
- Genotype
- Hepatitis Antibodies
(immunology)
- Hepatitis D, Chronic
(drug therapy, genetics, immunology)
- Hepatitis Delta Virus
(genetics, immunology)
- Humans
- Interferon-alpha
(therapeutic use)
- Interferons
- Interleukins
(genetics)
- Longitudinal Studies
- Male
- Middle Aged
- Polymorphism, Single Nucleotide
- RNA, Viral
(blood)
- Remission, Spontaneous
- Retrospective Studies
- Treatment Outcome
- Viral Load
- White People
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