Abstract |
Abstract We investigated the expression of membrane-type matrix metalloproteinase (MT- MMP) and matrix metalloproteinase ( MMP) mRNAs in synovial tissue from patients with rheumatoid arthritis (RA, n = 5) or osteoarthritis (OA, n = 5) by Northern blot analysis. Northern analysis demonstrated strong expression of MT1-MMP, MT3-MMP, MMP-1, and MMP-3 and weak expression of MT2-MMP and MMP-8 in synovial tissue from patients with RA or OA. MT4-MMP was not detected. No significant difference was shown in the expression of MT- MMP mRNAs between RA and OA. Synovial tissue of RA or OA patients expressed MT- MMPs as well as MMPs. These results indicate that, in addition to MMPs, MT1-MMP, MT3-MMP, and probably MT2-MMP may play a role in the degradation of bone and cartilage matrix in RA and OA. Such information may provide a clue to the development of a novel therapeutic approach targeted on the prevention of joint destruction.
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Authors | H Mitsui, N Tsuchiya, S Okinaga, K Matsuta, K Yoshimura, A Nishimura |
Journal | Modern rheumatology
(Mod Rheumatol)
Vol. 11
Issue 1
Pg. 34-9
(Mar 2001)
ISSN: 1439-7595 [Print] England |
PMID | 24387018
(Publication Type: Journal Article)
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