Successful treatment of homozygous familial hypercholesterolemia using cascade filtration plasmapheresis.

Abstract

OBJECTIVE:

The aim of this study was to report the efficacy of low-density lipoprotein cholesterol (LDL-C) apheresisusing a cascade filtration system in pediatric patients with homozygous familial hypercholesterolemia (FH), and toclarify the associated adverse effects and difficulties.

MATERIAL AND METHODS:

LDL-C apheresis using a cascade filtration system was performed in 3 pediatric patientswith homozygous FH; in total, 120 apheresis sessions were performed.

RESULTS:

Cascade filtration therapy significantly reduced the mean LDL-C values from 418 ± 62 mg/dL to 145 ± 43 mg/dL (p= 0.011). We observed an acute mean reduction in the plasma level of total cholesterol (57.9%), LDL-C (70.8%),and high-density lipoprotein cholesterol (HDL-C) (40.7%). Treatments were well tolerated. The most frequent clinicaladverse effects were hypotension in 3 sessions (2.5%), chills (1.7%) in 2 sessions, and nausea/vomiting in 3 sessions(2.5%).

CONCLUSION:

Our experience using the cascade filtration system with 3 patients included good clinical outcomes andlaboratory findings, safe usage, and minor adverse effects and technical problems.

CONFLICT OF INTEREST:

None declared.

• Authors: Fatih Kardaş, Aysun Cetin, Musa Solmaz, Rüksan Büyükoğlan, Leylagül Kaynar, Mustafa Kendirci, Bülent Eser, Ali Unal
• Journal: Turkish journal of haematology : official journal of Turkish Society of Haematology (Turk J Haematol) Vol. 29 Issue 4 Pg. 334-41 (Dec 2012) ISSN: 1300-7777 [Print] Turkey
• PMID: 24385721 (Publication Type: Journal Article)