To investigate the association between intra-articular (IA) large joint
corticosteroid injections and clinical outcomes in patients with recent onset
rheumatoid arthritis (RA). We compared
pain (visual analog scale (VAS)), the Disease Activity Score (44 joints) (
DAS), and swollen and tender joint counts before and after IA injection. Using linear mixed models (LMM), the
DAS and the Health Assessment Questionnaire (
HAQ) score over time were compared in IA injected versus noninjected patients. In year 1, 93 joints were injected in 44 patients treated with initial
methotrexate monotherapy and 16 in patients treated with initial combination
therapy (p < 0.01). Three months later, swelling and tenderness were resolved in 58-50 % of the injected joints; but within 12 months after the injection, swelling recurred in 14 % and tenderness in 41 % of the injected joints. Mean (SD)
DAS decreased from 4.0 (1.4) before to 3.2 (1.2) 3 months after injection (p < 0.01) and VAS for
pain from 49 (26) to 40 (27) (p < 0.01). LMM showed a higher
DAS and
HAQ in patients injected in year 0-1 compared to those not injected, but no difference in subsequent years, and similar treatment adjustments. Eight-year radiographs showed similar damage in injected joints (17 %) and noninjected joints (14 %). IA
corticosteroid injections are associated with symptom relief, sometimes only temporarily, in 50 % of cases. Initially
DAS significantly improved, but over time
DAS and
HAQ were similar in injected versus non-injected patients. After 8 years there was no difference in joint damage.