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EFdA, a reverse transcriptase inhibitor, potently blocks HIV-1 ex vivo infection of Langerhans cells within epithelium.

AuthorsTakamitsu Matsuzawa, Tatsuyoshi Kawamura, Youichi Ogawa, Kenji Maeda, Hirotomo Nakata, Kohji Moriishi, Yoshio Koyanagi, Hiroyuki Gatanaga, Shinji Shimada, Hiroaki Mitsuya
JournalThe Journal of investigative dermatology (J Invest Dermatol) Vol. 134 Issue 4 Pg. 1158-1161 (Apr 2014) ISSN: 1523-1747 [Electronic] United States
PMID24384694 (Publication Type: Letter, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Anti-HIV Agents
  • Anti-Infective Agents
  • Diazonium Compounds
  • Reverse Transcriptase Inhibitors
  • epoxyfarnesyl diazoacetate
  • Farnesol
Topics
  • Administration, Topical
  • Animals
  • Anti-HIV Agents (administration & dosage, chemistry)
  • Anti-Infective Agents (administration & dosage, chemistry)
  • CD4-Positive T-Lymphocytes (drug effects)
  • Coculture Techniques
  • Diazonium Compounds (administration & dosage, chemistry)
  • Dose-Response Relationship, Drug
  • Epithelium (drug effects, metabolism)
  • Farnesol (administration & dosage, analogs & derivatives, chemistry)
  • HIV Infections (prevention & control)
  • HIV-1 (drug effects)
  • Humans
  • Langerhans Cells (cytology, drug effects, virology)
  • Mice
  • Reverse Transcriptase Inhibitors (administration & dosage, chemistry)
  • Skin (drug effects, metabolism)

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