HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis.

Abstract
To examine the mechanisms by which licochalcone B (LCB) inhibits the proliferation of human malignant bladder cancer cell lines (T24 and EJ) in vitro and antitumor activity in vivo in MB49 (murine bladder cancer cell line) tumor model. Exposure of T24 or EJ cells to LCB significantly inhibited cell lines proliferation in a concentration-dependent and time-dependent manner, and resulted in S phase arrest in T24 or EJ cells, respectively. LCB treatment decreased the expression of cyclin A, cyclin-dependent kinase (CDK1 and CDK2) mRNA, cell division cycle 25 (Cdc25A and Cdc25B) protein. In addition, LCB treatment down-regulated Bcl-2 and survivin expression, enhanced Bax expression, activated caspase-3 and cleaved poly (ADP-ribose) polymerase (PARP) protein. Consistently, the tumorigenicity of LCB-treated MB49 cells was limited significantly by using the colony formation assay in vitro and the MB49 tumor model performed in C57BL/6 mice in vivo. These findings provide support for the use of LCB in chemoprevention and bladder cancer therapy.
AuthorsXuan Yuan, Tao Li, Erlong Xiao, Hong Zhao, Yongqian Li, Shengjun Fu, Lu Gan, Zhenhua Wang, Qiusheng Zheng, Zhiping Wang
JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association (Food Chem Toxicol) Vol. 65 Pg. 242-51 (Mar 2014) ISSN: 1873-6351 [Electronic] England
PMID24384411 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier Ltd. All rights reserved.
Chemical References
  • Cell Cycle Proteins
  • Chalcones
  • DNA Primers
  • licochalcone B
Topics
  • Animals
  • Apoptosis (drug effects)
  • Base Sequence
  • Blotting, Western
  • Cell Cycle (drug effects)
  • Cell Cycle Proteins (metabolism)
  • Cell Division (drug effects)
  • Cell Line, Tumor
  • Chalcones (pharmacology)
  • DNA Primers
  • Humans
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Polymerase Chain Reaction
  • Urinary Bladder Neoplasms (metabolism, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: