Multiple gene-to-gene interactions in children with sepsis: a combination of five gene variants predicts outcome of life-threatening sepsis.

Abstract

INTRODUCTION:

The aim of the study was to identify the dependency structure of genetic variants that can influence the outcome for paediatric patients with sepsis.

METHODS:

We evaluated the role of single nucleotide polymorphisms for five genes: bactericidal permeability increasing protein (BPI; rs5743507), lipopolysaccharide-binding protein (LBP; rs2232618), toll-like receptor 4 (TLR4; rs4986790), heat shock protein 70 (HSP 70; rs2227956), and interleukin 6 (IL-6; rs1800795) in 598 children aged 0 to 19 years that were admitted to a paediatric intensive care unit with fever, systemic inflammatory response syndrome, sepsis, severe sepsis, septic shock, or multiple organ dysfunction syndrome. A control group of 529 healthy individuals was included. Multi-way contingency tables were constructed and statistically evaluated using log-linear models. Typical gene combinations were found for both study groups.

RESULTS:

Detailed analyses of the five studied gene profiles revealed significant differences in sepsis survival. Stratification into high-risk, intermediate-risk, and low-risk groups of paediatric patients can predict the severity of sepsis.

CONCLUSIONS:

Analysis of single nucleotide polymorphisms for five genes can be used as a predictor of sepsis outcome in children.

• Authors: Petr Jabandziev, Michal Smerek, Jaroslav Michalek, Michal Fedora, Lucie Kosinova, Jaroslav A Hubacek, Jaroslav Michalek
• Journal: Critical care (London, England) (Crit Care) Vol. 18 Issue 1 Pg. R1 (Jan 02 2014) ISSN: 1466-609X [Electronic] England
• PMID: 24383711 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Adolescent
• Adult
• Aged
• Child
• Child, Preschool
• Epistasis, Genetic (genetics)
• Female
• Genetic Variation (genetics)
• Humans
• Infant
• Infant, Newborn
• Male
• Middle Aged
• Polymorphism, Single Nucleotide (genetics)
• Predictive Value of Tests
• Prospective Studies
• Sepsis (diagnosis, genetics, mortality)
• Survival Rate (trends)
• Treatment Outcome
• Young Adult