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Facile synthesis and intraparticle self-catalytic oxidation of dextran-coated hollow Au-Ag nanoshell and its application for chemo-thermotherapy.

Abstract
Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au-Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au-Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au-Ag nanoshell as a combinational chemo-thermotherapy to treat cancer cells.
AuthorsHongje Jang, Young-Kwan Kim, Hyun Huh, Dal-Hee Min
JournalACS nano (ACS Nano) Vol. 8 Issue 1 Pg. 467-75 (Jan 28 2014) ISSN: 1936-086X [Electronic] United States
PMID24383549 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antibiotics, Antineoplastic
  • Dextrans
  • Silver
  • Gold
  • Doxorubicin
Topics
  • Antibiotics, Antineoplastic (pharmacology)
  • Catalysis
  • Dextrans (chemistry)
  • Doxorubicin (pharmacology)
  • Gold (chemistry)
  • HeLa Cells
  • Humans
  • Hyperthermia, Induced
  • Metal Nanoparticles
  • Oxidation-Reduction
  • Silver (chemistry)
  • Spectrophotometry, Ultraviolet

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