Abstract |
Galvanic replacement reaction is a useful method to prepare various hollow nanostructures. We developed fast and facile preparation of biocompatible and structurally robust hollow Au-Ag nanostructures by using dextran-coated Ag nanoparticles. Oxidation of the surface dextran alcohols was enabled by catalytic activity of the core Au-Ag nanostructure, introducing carbonyl groups that are useful for further bioconjugation. Subsequent doxorubicin (Dox) conjugation via Schiff base formation was achieved, giving high payload of approximately 35 000 Dox per particle. Near-infrared-mediated photothermal conversion showed high efficacy of the Dox-loaded Au-Ag nanoshell as a combinational chemo- thermotherapy to treat cancer cells.
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Authors | Hongje Jang, Young-Kwan Kim, Hyun Huh, Dal-Hee Min |
Journal | ACS nano
(ACS Nano)
Vol. 8
Issue 1
Pg. 467-75
(Jan 28 2014)
ISSN: 1936-086X [Electronic] United States |
PMID | 24383549
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibiotics, Antineoplastic
- Dextrans
- Silver
- Gold
- Doxorubicin
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Topics |
- Antibiotics, Antineoplastic
(pharmacology)
- Catalysis
- Dextrans
(chemistry)
- Doxorubicin
(pharmacology)
- Gold
(chemistry)
- HeLa Cells
- Humans
- Hyperthermia, Induced
- Metal Nanoparticles
- Oxidation-Reduction
- Silver
(chemistry)
- Spectrophotometry, Ultraviolet
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