New routes towards reutericyclin analogues.

Abstract

A range of N-acylpyrrolo[3,4-c]isoxazoles and derived N-acyltetramides has been prepared via a nitrile oxide dipolar cycloaddition approach, as analogues of the acyltetramic acid metabolite reutericyclin, of interest for its antibiotic potential against Gram-positive bacteria including hospital-acquired infections of resistant Clostridium difficile.

• Authors: Raymond C F Jones, James P Bullous, Carole C M Law, Mark R J Elsegood
• Journal: Chemical communications (Cambridge, England) (Chem Commun (Camb)) Vol. 50 Issue 13 Pg. 1588-90 (Feb 14 2014) ISSN: 1364-548X [Electronic] England
• PMID: 24382380 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Bacterial Agents
• Isoxazoles
• reutericyclin
• Tenuazonic Acid

Topics

• Anti-Bacterial Agents (chemical synthesis, chemistry)
• Clostridioides difficile (drug effects)
• Enterocolitis, Pseudomembranous (drug therapy)
• Humans
• Isoxazoles (chemical synthesis, chemistry)
• Lactobacillus (chemistry)
• Models, Molecular
• Tenuazonic Acid (analogs & derivatives, chemical synthesis, chemistry)