Abstract | BACKGROUND: METHODS: In this multi-center, 8-week, double-blind study, adults who had received ≥8 weeks of stable statin therapy and had hypertriglyceridemia (TG level at 2.3-6.5 mmol/L) were randomized to receive CoA 400 U/d or placebo plus stable dosage of statin. Efficacy was assessed by the changes in the levels and patterns of lipoproteins. Tolerability was assessed by the incidence and severity of adverse events (AEs). RESULTS: A total of 304 patients with mixed hyperlipidemia were randomized to receive CoA 400 U/d plus statin or placebo plus statin (n = 152, each group). After treatment for 8 weeks, the mean percent change in TG was significantly greater with CoA plus statin compared with placebo plus statin (-25.9% vs -4.9%, respectively; p = 0.0003). CoA plus statin was associated with significant reductions in TC (-9.1% vs -3.1%; p = 0.0033), LDL-C (-9.9% vs 0.1%; p = 0.003), and non- high-density lipoprotein cholesterol (-13.5% vs -5.7%; p = 0.0039). There was no significant difference in the frequency of AEs between groups. No serious AEs were considered treatment related. CONCLUSIONS: TRIAL REGISTRATION: Current Controlled Trials ClinicalTrials.gov ID NCT01928342.
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Authors | Jiangtao Lai, Bifeng Wu, Tianming Xuan, Zhong Liu, Junzhu Chen |
Journal | Lipids in health and disease
(Lipids Health Dis)
Vol. 13
Pg. 1
(Jan 02 2014)
ISSN: 1476-511X [Electronic] England |
PMID | 24382338
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Triglycerides
- Coenzyme A
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Topics |
- Adult
- Aged
- Coenzyme A
(administration & dosage, adverse effects)
- Double-Blind Method
- Drug Therapy, Combination
- Dyslipidemias
(drug therapy)
- Female
- Humans
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
(adverse effects, therapeutic use)
- Male
- Middle Aged
- Treatment Outcome
- Triglycerides
(blood)
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