Abstract |
Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP. The results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in tail immersion test. However, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.
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Authors | Abbas Ahmadi, Mohsen Khalili, Ramin Hajikhani, Leila Barghi, Farnaz Mihandoust |
Journal | Iranian journal of pharmaceutical research : IJPR
(Iran J Pharm Res)
Vol. 9
Issue 4
Pg. 379-85
( 2010)
ISSN: 1735-0328 [Print] Netherlands |
PMID | 24381602
(Publication Type: Journal Article)
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