Abstract |
Multicentric Castleman's disease (MCD) is a rare lymphoproliferative disorder found with a higher frequency in HIV-seropositive patients. Human herpes virus 8 is found in virtually all cases of HIV-associated MCD. The majority of cases of MCD in patients with HIV are also associated with Kaposi's sarcoma. The dysregulated production of human IL-6 is thought to be an important factor in the pathogenesis of MCD. HIV-seropositive individuals with MCD have a significantly greater risk of developing non-Hodgkin lymphomas than their HIV-seronegative counterparts. MCD occurring in HIV patients has been associated with a poor prognosis. With newer therapy regimens, it is hoped that the prospects of HIV-infected patients with MCD will improve.
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Authors | John R Krause, Sara D Robinson, Estil A Vance |
Journal | Proceedings (Baylor University. Medical Center)
(Proc (Bayl Univ Med Cent))
Vol. 27
Issue 1
Pg. 28-30
(Jan 2014)
ISSN: 0899-8280 [Print] United States |
PMID | 24381398
(Publication Type: Case Reports)
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