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Acetylpuerarin reduces inflammation and improves memory function in a rat model of Alzheimer's disease induced by Abeta1-42.

Abstract
This study was performed to determine if acetylpuerarin (compound N-2211) could reduce amyloid-beta1-42 (Abeta1-42) induced learning and memory deficits and to examine its anti-neuroinflammatory effects in a rat model. Forty Wistar rats were randomly divided into four groups (n = 10 each): control, model (Abeta1-42 injected), low-dose and high-dose acetylpuerarin groups. The acetylpuerarin groups received peritoneal acetylpuerarin every day for 12 days after 2 weeks of Abeta1-42 (5 microg/1 microl) intrahippocampal injections. The Morris water maze (MWM) was used to assess rats' learning and memory abilities. Immunohistochemistry was used to assess expression levels of ionized calcium-binding adaptor molecule (Ibal), protein kinase C delta (PKCdelta), IkappaB kinase beta (IKKbeta), and inducible nitric oxide synthase (iNOS) in hippocampus. After Abeta1-42 injection, the learning and memory abilities of rats were reduced, and acetylpuerarin treatment ameliorated the observed deficits. Abeta1-42 injection resulted in microglia transforming from resting microglia into an activated state, but this was reduced by acetylpuerarin treatment. Furthermore, hippocampal expression of PKCdelta, IKKbeta, and iNOS increased following Abeta1-42 treatment, and acetylpuerarin could suppressed the levels of PKCdelta, iNOS, and IKKbeta. Acetylpuerarin improves learning and memory functions in Abeta1-42 induced rat models. These effects may be due to anti-neuroinflammatory effects.
AuthorsQ H Meng, F L Lou, W X Hou, M Liu, H Guo, X M Zhang
JournalDie Pharmazie (Pharmazie) Vol. 68 Issue 11 Pg. 904-8 (Nov 2013) ISSN: 0031-7144 [Print] Germany
PMID24380241 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Amyloid beta-Peptides
  • Anti-Inflammatory Agents, Non-Steroidal
  • Isoflavones
  • Peptide Fragments
  • acetylpuerarin
  • amyloid beta-protein (1-42)
  • Nitric Oxide Synthase Type II
  • I-kappa B Kinase
  • Protein Kinase C-delta
Topics
  • Alzheimer Disease (chemically induced, drug therapy, psychology)
  • Amyloid beta-Peptides
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Brain Chemistry (drug effects)
  • Female
  • I-kappa B Kinase (metabolism)
  • Immunohistochemistry
  • Isoflavones (pharmacology)
  • Maze Learning (drug effects)
  • Memory Disorders (drug therapy, psychology)
  • Microglia (drug effects)
  • Nitric Oxide Synthase Type II (biosynthesis)
  • Peptide Fragments
  • Protein Kinase C-delta (metabolism)
  • Rats
  • Rats, Wistar

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