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Polyarthritis caused by methimazole in two Japanese patients with graves' disease.

Abstract
In many countries, methimazole (MMI) therapy is the first-line treatment in children with Graves' disease (GD). The rate of side effects of antithyroid drugs (ATDs) in children has been reported to range between 6% and 35%. Of these side effects, polyarthritis is uncommon but serious, and can also develop as a part of the antineutrophil cytoplasmic antibody-associated vasculitis that is induced by ATDs. Here, we describe two GD girl patients aged 15 years and 11 years who developed polyarthritis. The onset of polyarthritis in these patients was 24 days and 28 days after the initiation of MMI therapy, respectively. MMI was suspected of causing the polyarthritis in the two patients and was withdrawn. The symptoms of polyarthritis disappeared rapidly following cessation of treatment. Subsequently, one patient was treated with 131I therapy and the other patient was subjected to thyroidectomy. Although it rarely occurs in pediatric GD patients, severe polyarthritis is a serious side effect of MMI and is an indication for prompt cessation of treatment.
AuthorsHiroko Nihei, Hidenori Tada, Yuki Naruse, Masako Izawa, Manji Kato, Hiroaki Okuno, Akie Nakamura, Katsura Ishizu, Takashi Hamajima, Toshihiro Tajima
JournalJournal of clinical research in pediatric endocrinology (J Clin Res Pediatr Endocrinol) Vol. 5 Issue 4 Pg. 270-2 ( 2013) ISSN: 1308-5735 [Electronic] Turkey
PMID24379039 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Antithyroid Agents
  • Methimazole
Topics
  • Adolescent
  • Antithyroid Agents (adverse effects)
  • Arthritis (chemically induced)
  • Child
  • Female
  • Graves Disease (drug therapy)
  • Humans
  • Methimazole (adverse effects)

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