The effect of recombinant human soluble thrombomodulin on disseminated intravascular coagulation in an abdominal aortic aneurysm.

Abstract

Aortic aneurysms are sometimes accompanied with disseminated intravascular coagulation (DIC). The definitive treatment of DIC is removal of underlying disease; surgical repair for the aortic aneurysms. Heparin, anticoagulant and other antifibrinolytic agents have been administered preoperatively to alleviate DIC whose bleeding tendency could cause high mortality and morbidity; however, their effectiveness was indeterminate. An 84-year-old man was presented with abdominal aortic aneurysm accompanied by DIC and underwent aneurysmectomy. After having confirmed that combined use of heparin and gabexate mesilate was ineffective, we used recombinant human soluble thrombomodulin (rhsTM), which has been reported to be more effective and safer than the heparin, for a week preoperatively, and demonstrated dramatic improvement of DIC. RhsTM should be a novel powerful therapeutic option for aneurysm-induced DIC.

• Authors: Katsuyuki Hoshina, Kunihiro Shigematsu, Akihiro Hosaka, Hiroyuki Okamoto, Tetsuro Miyata, Toshiaki Watanabe
• Journal: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis (Blood Coagul Fibrinolysis) Vol. 25 Issue 4 Pg. 389-91 (Jun 2014) ISSN: 1473-5733 [Electronic] England
• PMID: 24378974 (Publication Type: Case Reports, Journal Article)

Chemical References

• Recombinant Proteins
• THBD protein, human
• Thrombomodulin
• Heparin

Topics

• Aged, 80 and over
• Aortic Aneurysm, Abdominal (blood, drug therapy, pathology)
• Disseminated Intravascular Coagulation (blood, drug therapy, etiology)
• Heparin (administration & dosage)
• Humans
• Male
• Recombinant Proteins (administration & dosage)
• Thrombomodulin (administration & dosage)